ACE-031 Peptide 1 mg

ACE-031 is a synthetic research peptide modeled on the activin receptor type IIB (ActRIIB), designed to function as a ligand trap for signaling proteins such as myostatin and other members of the TGF-β superfamily. By interfering with ActRIIB ligand interactions, ACE-031 enables focused investigation into mechanisms of muscle growth regulation, bone metabolism, and tissue adaptation. Supplied as a high-purity 1 mg lyophilized powder, this peptide is intended strictly for research use only and is not for medical or therapeutic applications.

Research Focus and Areas of Interest

1. Myostatin Inhibition and Muscle Growth

ACE-031 mimics part of the ActRIIB binding domain, enabling it to interact with ligands such as myostatin (GDF-8). Through this interaction, researchers can study the inhibition of myostatin signaling and its downstream effects on skeletal muscle development, including hypertrophy and protein synthesis regulation.

2. Musculoskeletal Metabolism

ACE-031 is frequently used in metabolic and musculoskeletal models to assess how interference with ActRIIB signaling pathways affects muscle mass, bone density, and fat deposition. It may provide insight into mechanisms underlying lean mass preservation, particularly under catabolic conditions.

3. Energy Regulation and Contractile Function

Preclinical models have employed ACE-031 to explore energy balance, fatigue resistance, and contractile efficiency. Its role in neuromuscular resilience and adaptation under stress or injury continues to drive interest in studies related to physical endurance and muscle integrity.

4. Degeneration and Cachexia Models

ACE-031 has been used in research targeting muscle-wasting conditions such as sarcopenia or cachexia, particularly in models simulating chronic illness, disuse, or age-related muscle decline. It provides a controlled method for evaluating interventions aimed at mitigating muscle atrophy.

Conclusion

ACE-031 (1 mg) is a research-grade peptide derived from the ActRIIB sequence, designed for studies involving myostatin inhibition, muscle regulation, and metabolic homeostasis. With a clean 25-amino acid sequence and strong specificity, it offers researchers a focused tool for probing musculoskeletal and degenerative signaling pathways. For research use only — not for medical or therapeutic applications.

Technical Information:

• Synonyms: ACE-031, ActRIIB peptide fragment, Myostatin-binding peptide

• Modified Single-Letter Amino Acid Sequence: AWRQNTRYSRIEAIKIQILSKLRL

• IUPAC Name: Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu

• Molecular Weight: 2956.5 g/mol

• CAS Number: 1621169‑52‑5

• PubChem CID: 118732224

• Further References: PubChem Entry

Stability: Store lyophilised protein at -20°c. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°c for a limited period of time. The lyophilised protein remains stable until expiry date when stored at -20°c.

Source: Biosynthesis

Reconstitution: Reconstitute with Bacteriostatic Water

Usage: Product is prepared for LABORATORY RESEARCH ONLY. ACE-031 for sale at Pure Peptides UK is limited to scientific research and education only – Only buy ACE-031 if you are a licenced researcher.